Performance of Hemoglobin A1c Assay Methods: Good Enough?
نویسندگان
چکیده
منابع مشابه
Performance of hemoglobin A1c assay methods: good enough?
Two very interesting articles on hemoglobin A1c (Hb A1c) 2 method performance appear in this issue of Clinical Chemistry. Woodworth et al. (1 ) use Hb A1c as an example of how the risk of reporting inaccurate results can be estimated to guide individualized QC strategies. They assess the risk of reporting unreliable Hb A1c results with 6 different methods in 4 academic medical centers; 5 are la...
متن کاملFew point-of-care hemoglobin A1c assay methods meet clinical needs.
Accurate and timely measurements of hemoglobin A1c (Hb A1c) 2 are an increasingly important challenge for clinical laboratories. As Hb A1c measurements are being used to answer new clinical questions, each new use of Hb A1c imposes requirements for the analytical performance of the methods used to measure it. Until recently, Hb A1c was used only as a key test for monitoring glycemic control in ...
متن کاملUtilization of assay performance characteristics to estimate hemoglobin A1c result reliability.
BACKGROUND Allowable total error (TE(a)) goals for hemoglobin (Hb) A(1c) require minimal assay imprecision and bias and implementation of a robust QC monitoring program. Here, we compare the combined influence on the risk of reporting unreliable results of TE(a) goals, a routine QC practice, and assay performance characteristics of 6 Hb A(1c) instruments across 4 academic medical centers. MET...
متن کاملAn automated "high-pressure" liquid-chromatographic assay for hemoglobin A1c.
An automated "high-pressure" liquid-chromatographic assay for hemoglobin A1c is described. We use a 45-min incubation in acetate buffer (pH 5.5) to eliminate labile glycated hemoglobins. In this automated system conventional modules are used but it incorporates a solvent-switching valve to select either of two buffers, which differ in pH and NaCl concentration. The chromatographic column contai...
متن کاملMeasurement of Hemoglobin A1c
Evaluation of glycemia is used for the diagnosis and management of patients with diabetes. Glucose and hemoglobin A1c (HbA1c) provide complementary information and both are used to assess an individual’s glycemic status. The concentration of glucose in the blood indicates the subject’s glycemia at the time of blood sampling. However, blood glucose concentrations are modified by numerous factors...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2014
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2014.225789